The Inuit are the descendants of what anthropologists call the Thule culture, a nomadic people who emerged from western Alaska around 1000 CE and spread eastwards across the Arctic, displacing the related Dorset culture (in Inuktitut, the Tuniit). Inuit legends speak of the Tuniit as “giants”, people who were taller and stronger than the Inuit, but who were easily scared off and retreated from the advancing Inuit. Researchers believe that the Dorset culture lacked dogs, boats and other technologies that gave the expanding Inuit society a large advantage over them. By 1300, the Inuit had settled west Greenland, and finally moved into east Greenland over the following century.

The Tuniit survived in Aivilik, Southampton and Coats Islands, until the beginning of the 20th century. They were known as Sadlermiut (Sallirmiut in the modern spelling). Their population had been ravaged by diseases brought by contact with Europeans, and the last of them fell in a flu epidemic caught from a passing whaler in 1902. The area has since been resettled by Inuit. Genetic research suggests that there was little or no intermarriage between the Tuniit and the Inuit over the thousand years of contact in the Canadian Arctic.